Détails de la réservation
- Le : 14 April 2022
- De : 13 h 30
- à : 15 h 00
- Salle : Salle de conférence
Détails de l'évènement
Sébastian Lillo
Equipe de Maya Saleh
"Immunometabolic regulation of myeloid cells in the control of glioblastom"
Abstract :
Glioblastomas (GB) are the most severe and deadliest brain tumors in adults. Survival is estimated < 15 months after diagnosis and with a relapse rate > 95%. The current treatment involves surgery and radiotherapy coupled with chemotherapy. Two characteristics explain this high relapse rate. 1) the infiltrative capacity of tumor cells outside of the hypoxic tumor core and 2) the unique composition of the tumor immune microenvironment (TME) that is sparce in T lymphocytes and natural killer (NK) cells but dominated by microglia- and monocyte-derived macrophages.Moreover, although this is the basic treatment in GB, surgery fails to remove infiltrating tumor cells and causes inflammatory and immunosuppressive trauma with might promote recurrence. Macrophages are at the center of these events because they can exert both pro- or anti-inflammatory functions. Their functions and phenotypes greatly depend on the environment and the immune context. However, their post-resection diversity and the pathways that determine their functions in primary growth and recurrence remain largely unknown. This project therefore aims to characterize the dynamics and molecular characteristics of macrophages and
their interactions with gliomas in order to identify new therapeutic targets.
Responsable
- Nom : Mamani Maria