Détails de la réservation
- Le : 23 March 2022
- De : 14 h 00
- à : 16 h 00
- Salle : Salle de conférence
Détails de l'évènement
Pierre Milpied
Centre d’Immunologie de Marseille-Luminy, France
"Tracking normal and malignant immune cell plasticity with integrative single-cell sequencing"
Résumé
In immune responses to vaccines, pathogens, or auto-antigens, B cells and B-helper T cells undergo significant molecular and cellular evolution (e.g. B-cell receptor (BCR) affinity maturation in germinal centers (GC), plasma cell differentiation, and T follicular helper (TFH) cell activation). Genetic, and epigenetic alterations may transform B and T cells into malignant clonal expansions that give rise to lymphomas. In my lab, we use integrative single-cell sequencing to study the dynamics and plasticity of normal and malignant B and T cells in normal immune responses and lymphomas. In my seminar, I will introduce the methods that we use for single-cell sequencing of B and T cells, then describe our most recent work on the plasticity of malignant B cells in follicular lymphoma, and malignant T cells in angioimmunoblastic T cell lymphomas. I will also cover some practical concepts of bioinformatics data analysis of single-cell sequencing data.
Responsable
- Nom : Duluc Dorothée