Détails de la réservation
- Le : 26 July 2017
- De : 14 h 00
- à : 15 h 00
- Salle : Salle de conférence
Détails de l'évènement
Professor Jeffrey Holt
Harvard Medical School, F.M. Kirby Neurobiology Center, Boston
"Function, dysfunction and restoration of sensory transduction channels in auditory hair cells"
Résumé
Molecular identification of ion channels that mediate sensory transduction has been a major focus in the field of sensory biology for many years, yet, the proteins that form sensory transduction channels required for hearing and balance have not been definitively identified. I will present the latest evidence that supports a role for transmembrane channel-like 1 (TMC1) in hair cell sensory transduction. Mutations in TMC1 cause deafness in mice and humans. In addition to investigating the basic function of TMC1, our lab uses mice that harbor TMC1 mutations as a model for human genetic deafness. We find that TMC1 gene therapy can restore sensory transduction and auditory function in Tmc1 mutant mice.
Invited by Didier Dulon
Responsable
- Nom : Dulon Didier