Détails de la réservation
- Le : 21 June 2022
- De : 11 h 00
- à : 12 h 30
- Salle : Amphi Centre Broca Nouvelle - Aquitaine
Détails de l'évènement
Erdem Karatekin
Assistant Professor
Department of Cellular and Molecular Physiology,
School of Medicine, and the Nanobiology Institute
Yale University, USA
"Dynamics of cell membrane tension and vesicle recycling"
Abstract :
Many cellular activities, such as cell migration, cell division, phagocytosis, and exo-endocytosis, generate and are regulated by membrane tension gradients. Membrane tension gradients drive membrane flows, but there is controversy over how rapidly plasma membrane flow can relax tension gradients. Here we show that membrane tension can propagate rapidly or slowly, spanning orders of magnitude in speed, depending on cell type. In a neuronal terminal specialized for rapid synaptic vesicle turnover, membrane tension equilibrates within seconds. By contrast, membrane tension does not propagate in neuroendocrine adrenal chromaffin cells secreting catecholamines. Stimulation of exocytosis causes a rapid, global decrease in the synaptic terminal membrane tension, which recovers slowly due to endocytosis. Thus, membrane flow and tension equilibration may be adapted to distinct membrane recycling requirements.
Responsable
- Nom : David Perrais