Détails de la réservation
- Le : 22 October 2021
- De : 11 h 00
- à : 12 h 30
- Salle : Amphi Centre Broca Nouvelle - Aquitaine
Détails de l'évènement
Marie-Pierre Moisan
Team leader
NutriNeuro
"Inflammation-related depression : from symptoms dimensions to molecular biomarkers"
Abstract :
Depression is the most common of mental disorders, representing the leading chronic condition and the first cause of years lived with disability. Mounting evidence suggests intricate bidirectional relationship between adiposity and depression, which may explain their similar and parallel growth. In the past decades, inflammation was revealed to be a key mediator of the relationship between adiposity and depression. The Nutripsy team has largely contributed to show that obesity and even obesogenic dietary habits are characterized by a low-grade inflammation that renders individuals vulnerable to neuropsychiatric symptoms. In this lecture, I will summarize recent clinical data from Nutripsy team reporting on detailed neuropsychiatric symptoms associated with inflammatory status according to obesity severity grades, the relative contribution of metabolic health and inflammation to depressive symptoms and the relationships of depressive symptoms with tryptophan metabolism. Then, I will present the results of a transcriptomic study comparing depressed and non-depressed obese subjects analyzed before and after a bariatric surgery revealing molecular pathways predictors of depressive symptoms intensity and of remission. This research programs aim to promote precision nutritional medicine applied to mental health, in a context where the efficacy of standard treatments remains mitigated.
Responsable
- Nom : Rodriguez Arnaud