Détails de la réservation
- Le : 17 June 2022
- De : 11 h 00
- à : 12 h 00
- Salle : Salle de conférence
Détails de l'évènement
Mark Grinstaff
Departments of Biomedical Engineering, Chemistry,
and Medicine, and Division of Materials Science and Engineering,
Boston University, Boston, MA 02215
"Expansile Nanoparticles for the Treatment of Intraperitoneal Mesothelioma"
Abstract :
The treatment outcomes for malignant peritoneal mesothelioma are poor and associated with high co-morbidities due to suboptimal drug delivery. Thus, there is an unmet need for new approaches that concentrate drug at the tumor for a prolonged period of time yielding improved antitumor efficacy and improved metrics of treatment success. A paclitaxel-loaded pH-responsive expansile nanoparticle (PTX-eNP) system is described that addresses these unique challenges to improve the outcomes for peritoneal mesothelioma. The synthesis of the eNPs is described followed by several particle characterization techniques, including qNano, DLS, SEM, and TEM that measure particle size as a function of pH and swelling time. The rate of tumoral uptake of eNPs is rapid and, subsequent disruption of autophagosomal trafficking leads to prolonged intracellular retention. Following intraperitoneal administration, eNPs rapidly and specifically localize to tumors within 4 hr of injection with persistent intratumoral retention for >14 days. The high tumor-specificity of PTX-eNPs leads to delivery of >100 times higher concentrations of drug in tumors compared to PTX alone. As a result, overall survival of animals with established mesothelioma more than doubled when animals were treated with multiple doses of PTX-eNPs compared to an equivalent dose of PTX (standard of care) or non-responsive PTX-loaded nanoparticles.
Responsable
- Nom : Vloeberghs Malika