Détails de la réservation
- Le : 29 May 2017
- De : 11 h 00
- à : 12 h 30
- Salle : Salle de conférence
Détails de l'évènement
Simone Niclou
Head of the NORLUX Neuro-Oncology Laboratory,
Luxembourg Institute of Health, Luxembourg,
Adjunct professor at the Kristian Gerhard Jebsen Brain Tumour Research Center,
Department of Biomedicine, University of Bergen, Bergen, Norway
“Resolving Genetic and Phenotypic Heterogeneity in Glioblastoma”
Résumé
The genetic and pathophysiological complexity of Glioblastomas represents a major obstacle for effective treatment. Extensive molecular profiling based on sequencing, transcriptomic, epigenetic and single cell analyses starts to provide a better delineation of tumour subtypes and underlying driver mutations. However such data also highlights the prominent heterogeneity between (inter) and within (intra) patient tumours. In our work, we aim to correlate genetic heterogeneity with differences in tumour phenotypes at the molecular, cellular and histopathological level. Data of GBM heterogeneity at the level of DNA ploidy and stem cell marker expression will be presented. Further I will discuss our established bank of patient-derived orthotopic xenografts (PDOX) that faithfully recapitulate human glioma and how they can be used to study treatment response in vivo. Our current understanding of inter- and intra-tumour heterogeneity will be presented and the challenges for effective therapies will be discussed.
Invitation : Andreas Bikfalvi – Inserm U 1029
Responsable
- Nom : Rocher Virginie