Détails de la réservation
- Le : 23 May 2017
- De : 14 h 00
- à : 15 h 30
- Salle : Salle de conférence
Détails de l'évènement
Dr Mei lei
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
CNRS-UMR7104 / INSERM U964 / Université de Strasbourg
"Keratinocytes in regulating skin immune responses: what do we learn from mouse models?"
Résumé
Skin immune responses are important for host defense against pathogenic microorganisms, but dysregulated immune responses in the skin also cause chronic inflammatory skin diseases including atopic dermatitis (AD). In this seminar, I will take two examples from our studies over last years using mouse genetic tools and experimental models, to illustrate how epidermal keratinocytes (KCs) are recognized as initiator and regulator of skin and systemic inflammatory responses: 1) KC-derived cytokine thymic stromal lymphopoietin (TSLP) plays a key role in driving and coordinating the Type 2 Immunity in AD pathogenesis, as well as in triggering the progression from AD to asthma; 2) epidermal stratum corneum barrier dysfunction, resulted from gene mutations or environmental stimuli, leads to AD-like skin inflammation and allergen sensitization. We believe that insights obtained from mouse studies will be crucial for understanding the pathogenesis of skin inflammatory diseases, and will help to develop therapeutic/preventative strategies.
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Invitation : Katia Boniface - INSERM U1035
Responsable
- Nom : Rocher Virginie