Détails de la réservation
- Le : 2 June 2017
- De : 11 h 00
- à : 13 h 00
- Salle : Salle de conférence
Détails de l'évènement
Michael OWEN
Director of MRC Centre for Neuropsychiatric Genetics and Genomics; Director/Clinical Professor, Division of Psychological Medicine and Clinical Neuroscience and Emeritus Director of the Neuroscience and Mental Health Research Institute, Cardiff University
"Genomics and the Nature of Schizophrenia"
Résumé
Recent genomic studies have begun to reveal the genetic architecture of schizophrenia and to give important insights into the nature of the disorder and its relationship to other psychiatric diagnoses. Genetic risk does not map onto the syndromic definitions of disease that are used in the clinic. This, along with the lack of clear boundaries between disorders, suggests that there are likely to be overlapping mechanisms at work and that current diagnostic categories may not be optimal for stratifying cases for research into aetiology and pathogenesis. However, despite the undoubted complexity and the fact that much of the genetic risk remains unaccounted for at the DNA level, there are encouraging signs that the genes implicated converge onto sets of plausible biological processes. In particular, recent genetic data point to defects of synaptic and dendritic function and implicate mechanisms involved in brain plasticity that are important in development and in learning and cognition. While these are almost certainly not the only processes involved, they provide robust entry points for clinical and basic neuroscience research.
Invitant : Bordeaux Neurocampus
Responsable
- Nom : Julia Goncalves