Détails de la réservation
- Le : 5 May 2017
- De : 11 h 00
- à : 13 h 00
- Salle : Salle de conférence
Détails de l'évènement
Conférence mensuelle - Peter Magill
Professor of Neurobiology and Deputy Director of the Medical Research Council Brain Network Dynamics Unit at the University of Oxford
"The external globus pallidus in health and Parkinsonism"
Résumé
It is widely held that the cardinal movement difficulties seen in Parkinson’s disease arise from the abnormal firing rates of neurons in the basal ganglia and their partner brain circuits. Electrophysiological recordings of basal ganglia neurons in vivo have confirmed the predicted firing rate changes (albeit inconsistently), but have also revealed disturbed firing patterns at the levels of single cells and larger neuronal networks. For example, dopamine loss in people with idiopathic Parkinson’s disease is associated with the emergence of excessively-synchronized oscillations within and across basal ganglia nuclei.
In this lecture, I will showcase how the use of clinically-relevant animal models of Parkinsonism has provided valuable new insights into the mechanisms underlying these inappropriate neuronal oscillations, with a focus on the cells and circuits of the external globus pallidus (GPe).
I will also highlight how studies of this basal ganglia nucleus in the dopamine-depleted state have advanced our understanding of its operations in health. After correlating the molecular, structural and physiological properties of GPe neurons across models, it is now clear that the GPe contains two major types of neuron that are well suited to perform a division of labor when orchestrating basal ganglia activity and behaviour.
Invitant : Bordeaux Neurocampus / NBA
Responsable
- Nom : Julia Goncalves