Détails de la réservation
- Le : 14 May 2018
- De : 11 h 00
- à : 12 h 30
- Salle : Salle de conférence
Détails de l'évènement
Thierry Walzer
Immunité innée dans les maladies infectieuses et autoimmunes – CIRI – Centre National
de Recherche en Infectiologie - Lyon
"NK cell maturation: from transcription factors to
anti-tumor functions"
Résumé
Natural Killer (NK) cells are innate lymphocytes with an important role in theearly defense against intracellular pathogens and in the immunesurveillance of tumors and metastases. We and others discovered in 2009that NK cells underwent a program of maturation including at least threediscrete stages. Over the years, we accumulated evidences that these threesubsets have complementary functions and distributions. In particular,terminal maturation is associated with a major switch in the trafficking mode that is essential for the control of metastases. Moreover, we identified several transcription factors and molecular pathways that altogether control the maturation program. I will present recent unpublished data that shed light on the role of several factors including mTOR, S1P5, T-bet and Eomes in NK cell maturation.
Invitation : Julie Dechanet-Merville – Immunoconcept Umr 5164
Responsable
- Nom : Rocher Virginie