Détails de la réservation
- Le : 6 July 2018
- De : 10 h 30
- à : 12 h 45
- Salle : Amphi Centre Broca Nouvelle - Aquitaine
Détails de l'évènement
Chris Dayas
PhD, Associate Professor , Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle/ Australia.
"Hypothalamic control of motivated behaviours"
Résumé
Chris’ laboratory focuses on the brain pathways that are involved in motivated behaviours and stress. His group studies the basic wiring of circuits controlling the activity of specific cell types in the hypothalamus and other nodes of the brain reward-seeking pathway including the amygdala, nucleus accumbens and midbrain. His group’s primary aim is to dissect the maladaptive rewiring that occurs in the brain which promotes pathological motivational states that can manifest as addictions, obesity and mood disorders such as anxiety and depression. He will present data on his lab’s recent work studying the molecular substrates of addiction vulnerability and the synaptic mechanisms responsible for potent reward and stress-induced rewiring of hypothalamic circuits. Part of his presentation will outline the contribution of the molecular signalling pathway mTOR in the development and expression of addiction relevant behaviours. Specifically, recent work from his lab has shown that central and peripheral ntra-nucleus accumbens injections of the mTOR inhibitor rapamycin can have long lasting protective effects on relapse-like behaviour by reducing synaptic protein translation.
Invitant : Stéphanie Caillé-Garnier, PhD, Addicteam ; INCIA , Université de Bordeaux
Responsable
- Nom : Caille-Garnier Stephanie