Détails de la réservation
- Le : 5 March 2018
- De : 14 h 30
- à : 16 h 30
- Salle : Amphi Centre Broca Nouvelle - Aquitaine
Détails de l'évènement
Tianchi CHEN
Mechano-Biology Institute, Singapore
Résumé
The migration of cells over heterogeneous substrates during wound healing or morphogenetic processes leads to cell shape changes driven by different organizations of the actin cytoskeleton. These cell shape changes in response to physical aspects of the cellular environment include large scale positive and negative curvatures at cellular edges related to either protrusions or contractile acto-myosin cables. However, the underlying cellular mechanism of this large-scale curvature sensing is not clear. Here, we show that concave edges promote the formation of a polarized actin structure with actin flow directed towards the cell edge. This anterograde flow pattern driven by high stress at the edges leads to a tension anisotropy gradient and the formation of suspended tangential contractile actin cables in the front, accompanied by a local polymerization-depolymerization gradient. This leads to a polarized organization of the actin cytoskeleton that is capable of extending into non-adherent regions while still maintaining contact with neighboring adhesive substrate through focal adhesions. These versatile functional structures may help cells sense and navigate their environment by adapting to external geometric and mechanical cues.
Invitation de Greg Giannone
Responsable
- Nom : Rossier Olivier