Détails de la réservation
- Le : 27 February 2018
- De : 11 h 00
- à : 12 h 30
- Salle : Salle de conférence
Détails de l'évènement
Giorgio Seano
Junior Group Leader
Tumor Microenvironment Laboratory
Institut Curie Research Center, Orsay-Paris
"In vivo dynamics and targeting of vessel co-option and mechanical stress in brain tumors"
Résumé:
Brain tumors are highly lethal and cause significant neurologic dysfunction. Tumors can grow as infiltrative or nodular. Understanding the tumor growth pattern might provide us with key discoveries of new brain tumors vulnerabilities and innovative neuroprotective strategies.
During the last five years in Boston, I extensively used intravital microscopy to study the in vivo dynamics of brain tumor growth.I will show the results from two parallel studies.
In the first, we demonstrated that specific brain tumors highly invade the surrounding tissue by using the pre-existing brain vasculature, phenomenon called vessel co-option. We investigated the molecular mechanisms underling this
pathological event and proposed new therapeutic strategies capable to improve survival in glioblastoma-bearing mice.
In the second project, we investigated the neurodamage caused by primary and metastatic brain tumors that grow nodularly. They push, generate mechanical stress and cause neurodamage. Thus, we proposed neuroprotective interventions that reduce the neurologic impairment given by tumor-generated mechanical forces.
These two parallel studies covered a large range of pathophysiological phenomena occurring in brain tumors and will provide my new team with the bases to build its own research field in tumor microenvironment and brain tumors.
Invité par Thomas Daubon
Responsable
- Nom : Rocher Virginie