Détails de la réservation
- Le : 30 January 2018
- De : 11 h 00
- à : 12 h 30
- Salle : Salle de conférence
Détails de l'évènement
Pascale Jeannin
« Immunité Innée et Immunothérapie »
Centre de Recherche en Cancérologie Nantes-Angers | Inserm U892
" IL-26: a novel soluble pattern recognition molecule with anti-viral properties"
Résumé
IL-26 is a member of the IL-10 family, overexpressed in numerous chronic inflammatory disorders (rheumatoid arthritis, Crohn’s disease, psoriasis, vasculitis). Intriguingly, IL-26 acts on immune cells despite the absence of its originally described receptor (IL-10R2/IL-20R1).
IL-26 exhibits non-conventional physicochemical properties (amphipaticity and cationicity), conferring to IL-26 the capacity to bind nucleic acids. We have observed that IL-26 binds to extracellular DNA (released during massive cell death) and that DNA-IL-26 complexes are internalized by immune cells and activate them via DNA sensors. The presence of circulating IL-26-DNA complexes has been detected in patients with chronic inflammatory disorders. More recently, we have observed that IL-26 interacts with viral HCV RNA and, consequently, may interfere with HCV replication.
These studies identify IL-26 as a novel nucleic acid-binding PRM which exhibits potent anti-viral properties and amplifies chronic inflammatory responses.
Invitation : Patrick Blanco – Immunoconcept Umr Cnrs 5164
Responsable
- Nom : Rocher Virginie