Détails de la réservation
- Le : 27 April 2018
- De : 11 h 00
- à : 13 h 00
- Salle : Amphi Centre Broca Nouvelle - Aquitaine
Détails de l'évènement
Louis-Philippe Bernier
Research Associate – Lab of Dr Brian MacVicar / University of British Columbia,
Djavad Mowafaghian/ Centre for Brain Health, Vancouver, Canada
"A role for brain pericytes in cerebrovascular regeneration after stroke"
Résumé
Brain pericytes of the neurovascular unit (NVU) are critical for the developmental maturation of cerebral blood vessels and for the integrity of the blood-brain barrier (BBB). Pericytes are perivascular mural cells that share similarities with mesenchymal progenitors (MP), a cellular pool critical in supporting peripheral tissue regeneration.
Therefore we examined what role brain pericytes play in repairing and restoring the cerebral microvasculature following stroke using a new transgenic MP reporter mouse that specifically identifies brain pericytes. Here we show that after stroke, pericytes enter the cell cycle to support cerebrovascular regeneration in a manner similar to their role during development. Following stroke, pericytes proliferate and migrate into the infarct region where they accumulate inside a border of reactive astrocytes.
The pericyte-astrocyte interface forms an angiogenic zone that progressively migrates into the ischemic core, thereby supporting a wave of tissue revascularization. Within a few weeks normal vessels with an intact BBB are found perfusing the previously ischemic cortical area. Using single-cell and population RNA sequencing, we identify transcriptional signatures of naïve pericyte subpopulations as well as a functional and transcriptional profile of activated pericytes following trauma.
Brain pericytes in the adult brain represent a ¬major progenitor population that can modify their phenotype to contribute to the regeneration of cerebral blood vessels following injury in a process that recapitulates their role in developmental vasculogenesis.
Invitant : Eric Boué-Grabot , DR CNRS, team : Pathophysiology of parkinsonian syndromes, IMN
Responsable
- Nom : Sonia Meynard