Détails de la réservation
- Le : 16 January 2018
- De : 11 h 00
- à : 13 h 30
- Salle : Amphi Centre Broca Nouvelle - Aquitaine
Détails de l'évènement
Robert Kalb
MD, research scientist at The Children’s Hospital of Philadelphia and a professor of Neurology at the
Perelman School of Medicine at the University of Pennsylvania
"The intricacy of glutamatergic synapses – some new players in the game"
Résumé
During early postnatal life, synaptic activity within circuits sculpt connectivity among neurons. NMDA-R mediated activity-dependent development during a critical period has been well explored and other pathways exist, operate in parallel, that are NMDA-R independent. Evidence is provided for a plasticity channel that involves AMPA-R assembled with GluA1, the synaptic scaffolding protein SAP97 and specific SAP97-binding partners including CRIPT.
While the cell biological processes governed by GluA1/SAP97/CRIPT are just beginning to be explored, they are likely to be critical for normal brain function.
Invité par l'équipe IINS d'Olivier Thoumine
Responsable
- Nom : Thoumine Olivier