Détails de la réservation
- Le : 12 December 2017
- De : 14 h 00
- à : 16 h 00
- Salle : Salle de conférence
Détails de l'évènement
Karen Hirschi
Professor of Medicine (Cardiology) and of Genetics;
Yale Cardiovascular Research Center
" Endothelial cell specification "
Résumé
Summary: a primary interest of our laboratory is to understand, at the cellular and molecular level, the events leading to blood vessel formation. We are specifically interested in the regulation of vascular cell commitment, differentiation and cell cycle progression, and defining signaling pathways that modulate these processes. We also aim to understand how some vascular cells acquire specialized functions, such as the generation and/or maintenance of multi-lineage stem/progenitor cells.
Kenneth Walsh
Aram v. Chobanian distinguished Professor, Medicine;
Boston University
"Planar cell polarity and clonal hematopoiesis : Two regulators of pathological cardiovascular remodeling"
Publications :
Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derive from Human Induced Pluripotent Stem Cells.
Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE.
Cell Transplant. 2017 Aug. PMID: 28901188
FGF-dependent metabolic control of vascular development.
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M.
Nature. 2017 May 11; 2017 May 3. PMID: 28467822
Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow.
Hirschi KK, Nicoli S, Walsh K
Dev Cell. 2017 Apr 10. PMID: 28399402
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.
Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu CL, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AA, Cooper MA, Andrés V, Hirschi KK, Martin KA, Walsh K.
Science. 2017 Feb 24; 2017 Jan 19. PMID: 28104796
The molecular basis of endothelial cell plasticity.
Dejana E, Hirschi KK, Simons M.
Nat Commun. 2017 Feb 9; 2017
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.
Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M.
Development. 2016 Dec 1; 2016
PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.
Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann 1.
Nat Commun. 2016 Nov 29; 2016
Isolation of Murine Embryonic Hemogenic Endothelial Cells.
Fang JS, Gritz EC, Marcelo KL, Hirschi KK.
J. Vis Exp. 2016 Jun 17; 2016 Jun 17. PMID: 27341393
Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture.
Cuchiara ML, Coşkun S, Banda OA, Horter KL, Hirschi KK, West JL.
Biotechnol Bioeng. 2016
Specification and function of hemogenic endothelium during embryogenesis.
Gritz E, Hirschi KK.
Cell Mol Life Sci. 2016 Apr; 2016 Feb 5. PMID: 26849156
Responsable
- Nom : Duplàa Cécile