Détails de la réservation
- Le : 31 October 2017
- De : 11 h 00
- à : 12 h 30
- Salle : Salle de conférence
Détails de l'évènement
Frédéric Bard
Institute of Molecular and Cell Biology,
A*STAR Singapore
"Activating an invasion glycocode through Golgi reorganization"
Résumé
It has been known for over 30 years that various cancer cells dramatically upregulate production of the one sugar O-glycan called Tn. But it has remained unclear why and how. In recent years, we have identified a pathway regulating the
Tn producing enzymes, the GALNTs. This GALNTs Activation (GALA) pathway is based on the relocation of the enzymes from the Golgi to ER, a Golgi reorganization leading to a massive increase in O-glycosylation. We have genetically dissected this pathway using high throughput microscopy and RNAi screening and found that it is
highly regulated. In addition, our recent results indicate that GALNTs relocation strongly promotes liver tumors growth through up-regulation of tissue invasion. I will discuss the mechanisms underlying this tumor promoting activity and how hyperglycosylation of cell surface proteins might form an invasion glycocode.
Invitation : Frédéric Saltel – U 1053 BaRITon
Responsable
- Nom : Rocher Virginie