Détails de la réservation
- Le : 14 December 2017
- De : 11 h 00
- à : 12 h 30
- Salle : Salle de conférence
Détails de l'évènement
Michel Tremblay
Goodman Cancer Center McGill University,
Montreal
" Deciphering the function of protein tyrosine phosphatases (PTPs) in Cancer"
Résumé
As PTPs serve as controls for each other functionally and experimentally, my laboratory chose to work simultaneously on several of these enzymes. Our research revolves around the following five PTPs; PTP-PEST (PTPN13), PTP1B (PTP-N1), TC-PTP (PTPN2), the LAR-PTPs subfamily and especially PTP-sigma (RPTPS), and the oncogenic PRL2 (PTP4A2). These enzymes remove the phosphate moiety from tyrosine and were considered tumor suppressor genes counteracting the protein tyrosine kinase family, of which over 70% have been associated with oncogenic activities. Yet, we have clearly shown that many PTPs are as oncogenic as they are tumor suppressors. Using gene knock-out technologies and other molecular approaches our laboratory generated various mouse models and assays for all these enzymes and demonstrated their functions in cancer and also in other human diseases. Data regarding these different models and research projects will be presented in this talk.
Invitation : Andreas Bikfalvi – Inserm U 1029
29
Responsable
- Nom : Rocher Virginie