Seminaire conference neurosciences Yun WANG "Both functional and structural KCC2 involve in epileptogenesis"

Détails de la réservation

Détails de l'évènement

Yun WANG

PhD, Professor Institutes of Brain Science, Fudan University, Shanghai 200032, China

 

"Both functional and structural KCC2 involve in epileptogenesis"

 

 

Résumé

Epilepsy is one of the most common serious neurological disorders affecting about 50 million people globally (WHO 2017). It is a group of neurological diseases characterized by epileptic seizures, which are episodes that can vary from brief and nearly undetectable to long periods of vigorous shaking, due to episodes of excessive electrical discharges in a group of brain cells. However, it is unknown under which circumstances the brain shifts into the activity of a seizure with its excessive synchronization. One of the mechanisms of epilepsy is either the up-regulation of excitatory circuits or down-regulation of inhibitory circuits, or both, following the unknown reasons, such as an injury to the brain, which leads to the decreased resistance of excitatory neurons to fire.

GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl−] concentration, which in adult depends on neuron specific K+-Cl- cotransporter-2 (KCC2). KCC2 has been found downregulated in both epileptic patients and various epileptic animal models. However, the temporal relationship between KCC2 downregulation and seizure induction and its relationship with the epileptogenesis is still unclear. In first part of this study, we focused on to explore the temporal relationship and the influence of KCC2 downregulation on epileptiform bursting activity induction, and our findings demonstrated that altered expression of KCC2 is not the consequence, but likely is the contributing factor for induction of epileptic seizure. In the second part of this study, we tempted to establish the relationship between membrane KCC2 and the excitatory synapse reorganization during epileptogenesis, and our preliminary experiment evidence indicated that the structral KCC2 is also an important factor in the progress of epileptogenesis.

Invitant : Christophe Mulle, IINS , Team leader

Responsable

  • Nom : Deris Yves