Détails de la réservation
- Le : 5 October 2022
- De : 11 h 00
- à : 12 h 15
- Salle : Salle de conférence
Détails de l'évènement
Sebastien G. Bouret
Lille Neuroscience & Cognition
Development and Plasticity of the Neuroendocrine Brain
Inserm, University of Lille, CHU Lille
"The not-so-sweet effect of maternal nutrition on metabolic programming and brain development"
The growing prevalence of obesity and associated diseases such as type II diabetes is an important health concern, including among children and pregnant women. Epidemiological and pre-clinical studies suggested that alterations of the metabolic and hormonal environments during critical periods of development are associated with increased risks for obesity and type 2 diabetes in later life. There is general recognition that the developing brain is more susceptible to environmental insults than the adult brain. In particular, there is growing appreciation that developmental programming of hypothalamic neuroendocrine systems by the perinatal environment represents a possible cause for these diseases. This lecture will summarize the major stages of hypothalamic development and discuss potential periods of vulnerability for the development of hypothalamic neurons involved in energy balance and glucose regulation. It will also provide an overview of evidence concerning the action of hormones (including leptin and ghrelin) in programming the development and organization of hypothalamic melanocortin circuits. Recent data on the impact of maternal nutrition and low-calorie sweeteners consumption in the development and organization of hypothalamic circuits that regulate feeding and glucose homeostasis will also be presented.
Invited by Agnès Nadjar (Magendie) and Xavier Fioramonti (NutriNeuro)
- Nom : Rodriguez Arnaud