Détails de la réservation
- Le : 25 May 2018
- De : 11 h 30
- à : 12 h 00
- Salle : Amphi Broca Nouvelle - Aquitaine
Détails de l'évènement
Professeur, PhD, Institute of Experimental Epileptology and Cognition Research,
Life and Brain Center University of Bonn Medical Center Sigmund-Freud Str. 25 53127 Bonn
"Mechanisms of sparse coding in the dentate gyrus"
The dentate gyrus is the most important relay station that transfers polysensory information from the entorhinal cortex into the hippocampus proper. Theoretical and experimental evidence suggests that sparse coding of granule cells is critical for the ability to discriminate similar sensory percepts. The talk will explore some intriguing properties of the dentate gyrus that support sparse coding. Firstly, unique features of the granule cell dendrites confer strong attenuation and linear integrative properties onto granule cells. Secondly, dentate granule cells are powerfully modulated by canonical GABAergic inhibition and cholinergic modulation in-vitro and in-vivo. The presentation will discuss how these mechanisms can be used to shape state-dependent input-output processing in the dentate gyrus.
Invitant : Valentin Nagerl, IINS / team leader: Synaptic Plasticity and Super-Resolution Microscopy
- Nom : deris yves